Carcinoma in situ of breast
Description
breast ductal carcinoma in situ: A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There is no evidence of invasion of the basement membrane. Currently, it is classified into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade DCIS. In this classification the DCIS grade is defined by a combination of nuclear grade, architectural growth pattern and presence of necrosis. The size of the lesion as well as the grade and the clearance margins play a major role in dictating the most appropriate therapy for DCIS.
Data source
| FinnGen phenocode | CD2_INSITU_BREAST |
| Hospital Discharge registry | ICD-10: D05 |
| Cause of Death registry | ICD-10: D05 |
| Sex specific endpoint | 2 |
| Include | CD2_INSITU_BREAST_LOBULAR, CD2_INSITU_BREAST_INTRADUCTAL, CD2_INSITU_BREAST_NOS |
| Level in the ICD-hierarchy | 2 |
| First defined in version | DF2 |
Ontology
| DOID | 0060074, 8791 |
| GWAS catalog | 0000432 |
| MESH | D000071960 |
Key figures
| Sex | All | Female | Male |
| Number of individuals | 768 | 768 | - |
| Unadjusted prevalence (%) | 0.44 | 0.77 | - |
| Mean age at first event (years) | 59.21 | 59.21 | - |
| Case fatality at 5-years (%) | 1.69 | 1.69 | - |
Heritability
| SNP-h2 liability | CI |
| 0.25 | [0.01, 0.49] |
Longitudinal metrics
| Sex | All | Female | Male |
| Median nb. of events per indiv. | 2 | 2 | - |
| Recurrence at 6 months (%) | 45.8 | 45.96 | - |
Associations
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