Problems related to negative life events in childhood

Description

chronic lymphocytic leukemia: B-cell chronic lymphocytic leukemia (B-CLL) is a type of B-cell non-Hodgkin lymphoma (see this term), and the most common form of leukemia in Western countries, affecting elderly adults (mean age of 67 and 72 years) with a slight male predominance (1.7:1), and characterized by a highly variable clinical presentation that can include asymptomatic disease or non-specific B-symptoms such as unintentional weight loss, severe fatigue, fever (without evidence of infection), and night sweats as well as cervical lymphadenopathy, splenomegaly and frequent infections. Some patients can also develop autoimmune complications such as autoimmune hemolytic anemia or immune thrombocytopenia (see these terms). The clinical course is extremely heterogeneous with survival ranging from a few months to several decades.

Data source
FinnGen phenocode Z21_PROBL_RELATED_NEGAT_LIFE_EVENTS_CHILDH
Hospital Discharge registry ICD-10: Z61
Cause of Death registry ICD-10: Z61
Level in the ICD-hierarchy 3
First defined in version DF4
Ontology
DOID 1040
GWAS catalog 0000095
MESH D015451

Key figures

Sex All Female Male
Number of individuals 200 143 57
Unadjusted prevalence (%) 0.11 0.14 0.08
Mean age at first event (years) 16.64 17.85 13.59
Case fatality at 5-years (%) 0.0 0.0 0.0

Longitudinal metrics

Sex All Female Male
Median nb. of events per indiv. 2 2 1
Recurrence at 6 months (%) 45.5 48.25 38.6

Associations

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