Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances

Description

kuru: A prion disease found exclusively among the Fore linguistic group natives of the highlands of new guinea. The illness is primarily restricted to adult females and children of both sexes. It is marked by the subacute onset of tremor and ataxia followed by motor weakness and incontinence. Death occurs within 3-6 months of disease onset. The condition is associated with ritual cannibalism, and has become rare since this practice has been discontinued. Pathologic features include a noninflammatory loss of neurons that is most prominent in the cerebellum, glial proliferation, and amyloid plaques. (From Adams et al., Principles of Neurology, 6th ed, p773)

Data source
FinnGen phenocode VWXY20_ACCIDENTAL_POISO_EXPOS_OTHER_UNSPE_DRUGS_MEDICAM_BIOLO_SUBST
Hospital Discharge registry ICD-10: X44
Cause of Death registry ICD-10: X44
Level in the ICD-hierarchy 5
First defined in version DF4
Ontology
DOID 648
GWAS catalog 1001008
MESH D007729
SNOMED CT 86188000

Key figures

Sex All Female Male
Number of individuals 19 8 11
Unadjusted prevalence (%) 0.01 0.01 0.01
Mean age at first event (years) 43.94 54.1 36.55
Case fatality at 5-years (%) 36.84 62.5 18.18

Longitudinal metrics

Sex All Female Male
Median nb. of events per indiv. 1 1 1
Recurrence at 6 months (%) - - -

Associations

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