Atopic dermatitis

Description

atopic eczema: A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.

Data source
FinnGen phenocode L12_ATOPIC
Hospital Discharge registry ICD-10: L20, ICD-8: 691
Hospital Discharge registry: exclude ICD-9 6918X
Cause of Death registry ICD-10: L20, ICD-8: 691
Cause of Death registry: exclude ICD-9 6918X
KELA reimboursements codes ANY
KELA reimbursements ICD-10: L20
Level in the ICD-hierarchy 3
First defined in version DF2
Ontology
DOID 3310
GWAS catalog 0000274
MESH D003876

Key figures

Sex All Female Male
Number of individuals 5311 3695 1616
Unadjusted prevalence (%) 3.05 3.73 2.15
Mean age at first event (years) 30.34 30.89 29.07
Case fatality at 5-years (%) 0.6 0.38 1.11

Heritability

SNP-h2 liability CI
0.1 [0.04, 0.17]

Longitudinal metrics

Sex All Female Male
Median nb. of events per indiv. 1 1 1
Recurrence at 6 months (%) 36.28 37.08 34.47

First-event distributions

Associations

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