Crohn disease ( strict definition, require KELA, min 2 HDR)

Description

Crohn's disease: A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement.

Data source
FinnGen phenocode K11_CD_STRICT2
Hospital Discharge registry ICD-10: K50, ICD-9: 555, ICD-8: 5630
Cause of Death registry ICD-10: K50, ICD-9: 555, ICD-8: 5630
Conditions required K11_KELACROHN&K11_CROHN_NEVT>1
Level in the ICD-hierarchy C
First defined in version DF3
Ontology
DOID 8778
GWAS catalog 0000384
MESH D003424
SNOMED CT 7620006

Key figures

Sex All Female Male
Number of individuals 553 324 229
Unadjusted prevalence (%) 0.32 0.33 0.3
Mean age at first event (years) 40.39 40.75 39.87
Case fatality at 5-years (%) 0.18 0.0 0.44

Longitudinal metrics

Sex All Female Male
Median nb. of events per indiv. 7 7 6
Recurrence at 6 months (%) 66.45 66.86 65.91

First-event distributions

Associations

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