Disorders of parathyroid gland


hypoparathyroidism: Hypoparathyroidism is is an endocrine disorder in which the parathyroid glands in the neck do not produce enough parathyroid hormone (PTH). Common signs and symptoms includeabdominal pain, brittle nails, cataracts, dry hair and skin,muscle cramps,tetany, pain in the face, legs, and feet, seizures, tingling sensation,and weakened tooth enamel (in children). It may be caused byinjury to the parathyroid glands (e.g., during surgery). Other causes, include low blood magnesium levels, a side effect of radioactive iodine treatment for hyperthyroidism , metabolic alkalosis , DiGeorge syndrome , and type I polyglandular autoimmune syndrome . The goal of treatment is to restore the calcium and mineral balance in the body.

Data source
FinnGen phenocode E4_PARATHYRO
Hospital Discharge registry ICD-10: E20/E21
Cause of Death registry ICD-10: E21/E20
Level in the ICD-hierarchy 3
First defined in version DF2
DOID 11199
GWAS catalog 0009451
MESH D010279
SNOMED CT 36976004

Key figures

Sex All Female Male
Number of individuals 2714 2124 590
Unadjusted prevalence (%) 1.56 2.14 0.79
Mean age at first event (years) 62.1 62.5 60.67
Case fatality at 5-years (%) 6.78 6.31 8.47

Longitudinal metrics

Sex All Female Male
Median nb. of events per indiv. 2 2 2
Recurrence at 6 months (%) 52.69 54.4 47.3


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