Acromegaly and pituitary gigantism

Description

hyperpituitarism: Disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone ; and adrenocorticotropic hormone. Hyperpituitarism usually is caused by a functional adenoma.

Data source
FinnGen phenocode E4_ACROMEG
Hospital Discharge registry ICD-10: E220, ICD-8: 2530
Hospital Discharge registry: exclude ICD-8 25301
Cause of Death registry ICD-10: E220, ICD-8: 2530
Cause of Death registry: exclude ICD-8 25301
Level in the ICD-hierarchy 4
First defined in version DF2
Ontology
DOID 2444
GWAS catalog 1000973
MESH D006964
SNOMED CT 10649000

Key figures

Sex All Female Male
Number of individuals 88 55 33
Unadjusted prevalence (%) 0.05 0.06 0.04
Mean age at first event (years) 44.97 43.67 47.13
Case fatality at 5-years (%) 0.0 0.0 0.0

Longitudinal metrics

Sex All Female Male
Median nb. of events per indiv. 7 5 11
Recurrence at 6 months (%) 69.32 61.82 81.82

Associations

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