Non-follicular lymphoma


neoplasm of mature B-cells: A neoplasm of follicle centre B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001).

Data source
Hospital Discharge registry ICD-10: C83, ICD-9: 200
Hospital Discharge registry: exclude ICD-9 200A
Cause of Death registry ICD-10: C83, ICD-9: 200
Cause of Death registry: exclude ICD-9 200A
Level in the ICD-hierarchy 3
First defined in version DF4
DOID 0050873, 706, 707
GWAS catalog 0000096
MESH D016393
SNOMED CT 269476000

Key figures

Sex All Female Male
Number of individuals 873 392 481
Unadjusted prevalence (%) 0.5 0.4 0.64
Mean age at first event (years) 61.73 60.72 62.56
Case fatality at 5-years (%) 13.29 11.73 14.55

Longitudinal metrics

Sex All Female Male
Median nb. of events per indiv. 5 6 5
Recurrence at 6 months (%) 67.93 68.11 67.78


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