Adult-onset Still disease

Description

adult-onset Still's disease: adult-onset Still disease (AOSD) is a rare inflammatory multisystem disorder characterized clinically by fever of unknown origin, arthralgia or arthritis, hyperleucocytosis, and typical skin rash.

Data source
FinnGen phenocode STILL_ADULT
Hospital Discharge registry ICD-10: M060
Cause of Death registry ICD-10: M060
Include STILL_ADULT, RHEUMA_NOS, RHEUMA_OTHER_WIDE
First defined in version DF2
Ontology
DOID 14256
GWAS catalog 0007135
MESH D016706
SNOMED CT 239920006, 68190001

Key figures

Sex All Female Male
Number of individuals 2587 1846 741
Unadjusted prevalence (%) 1.48 1.86 0.99
Mean age at first event (years) 49.85 48.91 52.2
Case fatality at 5-years (%) 2.78 2.17 4.32

Longitudinal metrics

Sex All Female Male
Median nb. of events per indiv. 3 3 3
Recurrence at 6 months (%) 55.55 56.72 52.63

Associations

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