Coeliac disease

Description

celiac disease: An autoimmune genetic disorder with an unknown pattern of inheritance that primarily affects the digestive tract. It is caused by intolerance to dietary gluten. Consumption of gluten protein triggers an immune response which damages small intestinal villi and prevents adequate absorption of nutrients. Clinical signs include abdominal cramping, diarrhea or constipation and weight loss. If untreated, the clinical course may progress to malnutrition, anemia, osteoporosis and an increased risk of intestinal malignancies. However, the prognosis is favorable with successful avoidance of gluten in the diet.

Data source
FinnGen phenocode K11_COELIAC
Hospital Discharge registry ICD-10: K900, ICD-9: 5790A
Cause of Death registry ICD-10: K900, ICD-9: 5790A
Level in the ICD-hierarchy 3
First defined in version DF2
Ontology
DOID 10608
GWAS catalog 0001060
MESH D002446
SNOMED CT 396331005

Key figures

Sex All Female Male
Number of individuals 1502 1013 489
Unadjusted prevalence (%) 0.86 1.02 0.65
Mean age at first event (years) 45.83 44.57 48.45
Case fatality at 5-years (%) 1.73 1.09 3.07

Longitudinal metrics

Sex All Female Male
Median nb. of events per indiv. 2 2 2
Recurrence at 6 months (%) 47.07 47.38 46.42

Associations

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