Eosinophilic disease (BM)

Description

Hypereosinophilic syndrome: The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil count (≥ 1500 eosinophils/mm³) in the blood for at least six months without any recognizable cause, with involvement of either the heart, nervous system, or bone marrow. HES is a diagnosis of exclusion, after clonal eosinophilia (such as leukemia) and reactive eosinophilia (in response to infection, autoimmune disease, atopy, hypoadrenalism, tropical eosinophilia, or cancer) have been ruled out.

Data source
FinnGen phenocode ESOSINOPHIL_DISEASE
Hospital Discharge registry ICD-10: D721
Cause of Death registry ICD-10: D721
First defined in version DF2
Ontology
DOID 999
GWAS catalog 1001467
MESH D007960
SNOMED CT 419455006

Key figures

Sex All Female Male
Number of individuals 139 76 63
Unadjusted prevalence (%) 0.08 0.08 0.08
Mean age at first event (years) 52.42 50.81 54.36
Case fatality at 5-years (%) 2.16 2.63 1.59

Longitudinal metrics

Sex All Female Male
Median nb. of events per indiv. 1 1 1
Recurrence at 6 months (%) 41.01 43.42 38.1

Associations

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