Allergic bronchopulmonary aspergillosis (ABPA)

Description

aspergillosis: Aspergillosis is an infection, growth, or allergic response caused by the Aspergillus fungus. There are several different kinds of aspergillosis. One kind is allergic bronchopulmonary aspergillosis (also called ABPA), a condition where the fungus causes allergic respiratory symptoms similar to asthma, such as wheezing and coughing, but does not actually invade and destroy tissue. Another kind of aspergillosis is invasive aspergillosis. This infection usually affects people with weakened immune systems due to cancer, AIDS, leukemia, organ transplantation, chemotherapy, or other conditions or events that reduce the number of normal white blood cells. In this condition, the fungus invades and damages tissues in the body. Invasive aspergillosis most commonly affects the lungs, but can also cause infection in many other organs and can spread throughout the body (commonly affecting the kidneys and brain). Aspergilloma , a growth (fungus ball) that develops in an area of previous lung disease such as tuberculosis or lung abscess , is a third kind of aspergillosis. This type of aspergillosis is composed of a tangled mass of fungus fibers, blood clots, and white blood cells. The fungus ball gradually enlarges, destroying lung tissue in the process, but usually does not spread to other areas.

Data source
FinnGen phenocode ABPA
Hospital Discharge registry ICD-10: B441
Cause of Death registry ICD-10: B441
First defined in version DF2
Ontology
DOID 13564
GWAS catalog 0007157
MESH D001228
SNOMED CT 65553006

Key figures

Sex All Female Male
Number of individuals 30 18 12
Unadjusted prevalence (%) 0.02 0.02 0.02
Mean age at first event (years) 62.49 60.81 65.01
Case fatality at 5-years (%) 10.0 11.11 8.33

Longitudinal metrics

Sex All Female Male
Median nb. of events per indiv. 2 3 2
Recurrence at 6 months (%) 66.67 72.22 58.33

Associations

Loading associations…